Internal Advisory Committee(IAC)
The Internal Advisory Committee consists of the Director, Deputy Director and Associate Directors (i.e., Drs. DiGiovanni, MacLeod, Bondy and Richburg, respectively), who comprise the Executive Committee, the Research Focus Area (RFA) Leaders (Drs. Bondy, Nairn, Fischer, and Walker), and the COEC Director (Dr. Fuchs-Young), the IAC now includes the Facility Core Directors (Drs. Shen, Gimenez-Conti, Richie, Person, and Strom), the Career Development Program Leander (Dr. Hursting) and the Center Business Manager (Kimberley Boedy). Thus, all three campuses are represented in the IAC meetings. Although the IAC had intended to meet on a quarterly basis, the meetings have actually occurred more frequently than that, averaging five per year in Years 6 through 8 and once a month in Year 9 and 10. An agenda and minutes of all IAC meetings are recorded and maintained by the CRED Administrator and kept in the CRED office. Topics commonly discussed at the IAC meetings include: membership changes, the pilot project program, equipment, research developments, Facility Core use and charging technologies, budgetary matters (including Facility Core allotments), ESAB visits, newsletters, retreats, seminars, symposia, COEC activities, Center grant renewal preparations, and progress reports.
External Scientific Advisory Board
Gerald N. Wogan, Ph.D. (Chair)
Dr. Wogan, Chairman of the ESAB, is Underwood-Prescott Professor, Emeritus, and Professor of Chemistry, Emeritus, in the Biological Engineering Division at Massachusetts Institute of Technology. He is also a member of the NIEHS Center for Environmental Health Sciences at MIT in the Toxicology and Epidemiology Program. Dr. Wogan is a nationally and internationally recognized authority on chemical carcinogenesis and carcinogen-induced DNA damage (especially aflatoxins). In addition, he has contributed significantly to methods for the detection of such DNA damage. Dr. Wogan also studies the relationship between exposure to environmental carcinogenesis, DNA damage, and cancer risk in human populations. Dr. Wogan is also a member of the National Academy of Sciences and the Institute of Medicine.
David L. Eaton, Ph.D.
Dr. Eaton received his Ph.D. in pharmacology from the University of Kansas Medical Center (KUMC) in 1978. He joined the faculty of the University of Washington in 1979, and is currently Professor and Director of the Center for Ecogenetics and Environmental Health at the University of Washington, and Associate Dean for Research in the School of Public Health and Community Medicine. Nationally, he has served as Secretary, and later as President, of the Society of Toxicology, and serves on numerous scientific advisory boards for other centers and program grants. He served on the NAS/NRC Board of Environmental Studies and Toxicology from 1996-1999, and as Chair of the NAS/NRC Committee on Emerging Issues and Data on Environmental Contaminants (2002-04). He is currently serving as Chair of the NAS/NRC/IOM Committee on Assessment of the Health Implications of Exposure to Dioxin. Dr. Eaton maintains his own active research and teaching program focused in the area of the molecular basis for environmental causes of cancer. He has published over 140 scientific articles and book chapters in the field of toxicology and risk assessment, and is an Elected Fellow of the American Association for the Advancement of Science and of the Academy of Toxicological Sciences.
Paul Meltzer, M.D., Ph.D
Dr. Meltzer is Head of the Section of Molecular Genetics, National Human Genome Research Institute, National Institutes of Health. His research focuses on the characterization of genetic alterations in cancer cells. Dr. Meltzer's areas of emphasis include gene expression, gene amplification, and chromosome abnormalities. His specific projects use tumor profiling technologies in human solid tumors, particularly breast cancer, sarcomas, and melanoma.
Stephen H. Safe, Ph.D.
Dr. Safe, Distinguished Professor, Veterinary Physiology & Pharmacology in the College of Veterinary Medicine at Texas A & M University, is also Program Director of the NIEHS Hazardous Substances Basic Research Program. He is also Deputy Director of the NIEHS Center for Environmental and Rural Health at Texas A&M University. Dr. Safe's research is focused on the genomic and non-genomic mechanisms of ligand-activated estrogen receptor (ER) in breast cancer and inhibitory Ah receptor-ER{alpha} crosstalk. His research is also focused on new ligands for orphan receptors and their applications for cancer chemotherapy and chemoprevention.
Gary Stoner, Ph.D.
Dr. Stoner is Lucius Wing Professor, Division of Hematology and Oncology in the Department of Internal Medicine at The Ohio State University. He is also Director of the Cancer Chemoprevention Program in the OSU Cancer Center. His research interests include: molecular carcinogenesis and cancer chemoprevention, focusing principally on tobacco-related cancers(i.e., lung, esophagus and oral cavity); the use of animal models and human tissue culture systems for investigations of carcinogen metabolism, carcinogen-DNA interactions, oncogene activation, and tumor suppressor gene inactivation; chemoprevention of tobacco-related cancers using single agents that target specific molecular pathways and food constituents such as freeze-dried berry preparations; and human clinical trials of cancer chemopreventive agents.
Leona D. Samson, Ph.D.
Dr. Samson is the Ellison American Cancer Society Research Professor, Professor of Biological Engineering and Toxicology, and Professor of Biology at the Massachusetts Institute of Technology. She is also the Director of the MIT Center for Environmental Health Sciences that is partially supported by a core grant from the NIEHS. Her research involves the study of carcinogenic alkylating agents and mechanisms of how cells, animals, and humans respond when exposed to these agents. Dr. Samson's research focuses on understanding the biology, biochemistry, and genetics of these responses.
Mary S. Wolff, Ph.D.
Mary S. Wolff, Ph.D., is Professor in the Department of Community and
Preventive Medicine as well as the Derald H. Ruttenberg Cancer Center
and Director of the Division of Environmental Health Science at the
Mount Sinai School of Medicine in New York, NY. She holds a Ph.D.
degree in chemistry, and her research interests center around
application of biological markers to determine exposures of humans to
chemicals that occur in the environment. She has published widely on
exposure assessment topics including air pollutants, lead, polycyclic
aromatic hydrocarbons, solvents, pesticides, and halogenated
hydrocarbons. Her research has attempted to incorporate available
knowledge of pharmacokinetic variability into exposure assessment.
From 1987- 2000, she investigated breast cancer risk associated with
environmental exposures and the genetic determinants of these risks
in a number of studies. More recently, the emphasis of her research
has shifted to childhood exposures and health risks. Dr. Wolff is
Director of the Center for Children's Environmental Health and
Disease Prevention Research, an NIH/EPA-funded multidisciplinary
research program to study urban exposures and infant development. She
and her colleagues in the Division of Epidemiology recently received
a 7-year grant from NIEHS to investigate environmental and genetic
risks for early puberty, research that is intended to elucidate
breast cancer risk. Other current interests include physical and
dietary modulation of environmental etiologies of disease.
